Standard Name	UBP8 1
Systematic Name	YMR223W
Feature Type	ORF, Verified
Description	Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B (2, 3)
Name Description	UBiquitin-specific processing Protease 1

Chromosomal Location	ChrXIII:716715 to 718130 | ORF Map | GBrowse

	View Computational GO annotations for UBP8
Molecular Function
Manually curated	protein complex scaffold (IDA, IMP) ubiquitin-specific protease activity (IMP)
Biological Process
Manually curated	histone deubiquitination (IMP) histone H3-K4 methylation (IMP) histone H3-K79 methylation (IMP)
Cellular Component
Manually curated	DUBm complex (IDA) SAGA complex (IDA) SLIK (SAGA-like) complex (IDA)

Classical genetics
null	gamma ray resistance: decreased heat sensitivity: increased metal resistance: increased
Large-scale survey
null	competitive fitness: decreased dessication resistance: decreased gamma ray resistance: decreased resistance to hygromycin B: increased resistance to spermine: increased resistance to tetramethylammonium: increased resistance to fluconazole: increased resistance to mycophenolic acid: increased resistance to tunicamycin: increased resistance to camptothecin: decreased resistance to sodium selenide: decreased resistance to bleomycin: increased sporulation efficiency: decreased stress resistance: increased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	550 total interaction(s) for 281 unique genes/features.
Physical Interactions	Affinity Capture-MS: 179 Affinity Capture-RNA: 1 Affinity Capture-Western: 32 Biochemical Activity: 7 Co-crystal Structure: 1 Co-localization: 3 Co-purification: 1 Reconstituted Complex: 2 Two-hybrid: 2
Genetic Interactions	Negative Genetic: 135 Phenotypic Enhancement: 4 Phenotypic Suppression: 7 Positive Genetic: 72 Synthetic Growth Defect: 18 Synthetic Lethality: 12 Synthetic Rescue: 74
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:716715 to 718130 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1416 716715..718130 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004836