ERG8/YMR220W Summary Help

Standard Name ERG8 1
Systematic Name YMR220W
Feature Type ORF, Verified
Description Phosphomevalonate kinase; an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate (2, 3 and see Summary Paragraph)
Name Description ERGosterol biosynthesis 1
Chromosomal Location
ChrXIII:712316 to 713671 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ERG8 GO evidence and references
  View Computational GO annotations for ERG8
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 5 genes
Resources
Pathways
Classical genetics
null
repressible
Large-scale survey
null
reduction of function
repressible
Resources
64 total interaction(s) for 59 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 3

Genetic Interactions
  • Negative Genetic: 48
  • Phenotypic Enhancement: 2
  • Positive Genetic: 6
  • Synthetic Lethality: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 451
Molecular Weight (Da) 50,454
Isoelectric Point (pI) 6.46
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:712316 to 713671 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1356 712316..713671 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004833
SUMMARY PARAGRAPH for ERG8

ERG8 encodes phosphomevalonate kinase, a cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol in yeast, from mevalonate (2, 3, 4). ERG8 is essential; the erg8-1 allele is temperature sensitive and lacks phosphomevalonate kinase activity (1, 2).

Last updated: 2000-08-22 Contact SGD

References cited on this page View Complete Literature Guide for ERG8
1) Karst F and Lacroute F  (1977) Ertosterol biosynthesis in Saccharomyces cerevisiae: mutants deficient in the early steps of the pathway. Mol Gen Genet 154(3):269-77
2) Tsay YH and Robinson GW  (1991) Cloning and characterization of ERG8, an essential gene of Saccharomyces cerevisiae that encodes phosphomevalonate kinase. Mol Cell Biol 11(2):620-31
3) Paltauf F, et al.  (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
4) Stryer L  (1995) Biochemistry (4th ed.). New York: W. H. Freeman and Company