Standard Name	SKY1 1
Systematic Name	YMR216C
Feature Type	ORF, Verified
Description	SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1 (1, 2)
Name Description	SRPK1-like Kinase in Yeast 1

Chromosomal Location	ChrXIII:701039 to 698811 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SKY1
Molecular Function
Manually curated	protein serine/threonine kinase activity (IDA)
High-throughput	protein kinase activity (IDA)
Biological Process
Manually curated	cellular cation homeostasis (IMP) cellular ion homeostasis (IMP) mRNA splice site selection (IGI) positive regulation of protein import into nucleus (IMP) protein phosphorylation (IDA) response to drug (IMP)
High-throughput	protein phosphorylation (IDA) regulation of cell size (IMP)
Cellular Component
Manually curated	cytoplasm (IDA)

Classical genetics
null	resistance to sirolimus: increased
Large-scale survey
null	cell cycle progression in G1 phase: increased duration cell size: decreased competitive fitness: decreased dessication resistance: decreased hyperosmotic stress resistance: increased resistance to mefloquine: decreased resistance to dimethyl sulfoxide: decreased resistance to quinine: decreased resistance to acetic acid: decreased resistance to ethanol: decreased resistance to citric acid: decreased resistance to tetramethylammonium: increased resistance to spermine: increased resistance to hygromycin B: increased resistance to cisplatin: increased resistance to BPS: decreased resistance to doxorubicin: decreased resistance to mycophenolic acid: decreased stress resistance: increased toxin resistance: increased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	369 total interaction(s) for 270 unique genes/features.
Physical Interactions	Affinity Capture-MS: 7 Affinity Capture-RNA: 2 Affinity Capture-Western: 1 Biochemical Activity: 47 Reconstituted Complex: 17 Two-hybrid: 2
Genetic Interactions	Dosage Growth Defect: 2 Dosage Lethality: 3 Dosage Rescue: 2 Negative Genetic: 148 Phenotypic Enhancement: 14 Phenotypic Suppression: 77 Positive Genetic: 36 Synthetic Growth Defect: 4 Synthetic Lethality: 3 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:701039 to 698811 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2229 701039..698811 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004829