VTI1/YMR197C Summary

VTI1 BASIC INFORMATION

Standard Name	VTI1 1
Systematic Name	YMR197C
Feature Type	ORF, Verified
Description	Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways (1, 2, 3)
Name Description	Vps10 (Ten) Interacting 1

GO Annotations	All VTI1 GO evidence and references
	View Computational GO annotations for VTI1
Molecular Function
Manually curated	SNAP receptor activity (TAS)
Biological Process
Manually curated	Golgi to vacuole transport (TAS) intra-Golgi vesicle-mediated transport (TAS) late endosome to vacuole transport (TAS) vesicle fusion (TAS)
Cellular Component
Manually curated	integral to Golgi membrane (IDA)

Mutant Phenotype	All VTI1 Phenotype details and references
Large-scale survey
null	inviable
overexpression	resistance to rapamycin: decreased

Interactions	VTI1 All interactions details and references
	102 total interaction(s) for 32 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 1 Affinity Capture-Western: 48 Co-fractionation: 4 Co-purification: 9 Reconstituted Complex: 17 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 12 Phenotypic Enhancement: 1 Synthetic Lethality: 3

Sequence Information

ChrXIII:659197 to 658544 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..654	659197..658544	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004810

VTI1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for VTI1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for VTI1]

1)	von Mollard GF, et al. (1997) The yeast v-SNARE Vti1p mediates two vesicle transport pathways through interactions with the t-SNAREs Sed5p and Pep12p. J Cell Biol 137(7):1511-24
2)	Lupashin VV, et al. (1997) Characterization of a novel yeast SNARE protein implicated in Golgi retrograde traffic. Mol Biol Cell 8(12):2659-76
3)	Fischer von Mollard G and Stevens TH (1999) The Saccharomyces cerevisiae v-SNARE Vti1p is required for multiple membrane transport pathways to the vacuole. Mol Biol Cell 10(6):1719-32

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