RGM1/YMR182C Summary Help

Standard Name RGM1 1
Systematic Name YMR182C
Feature Type ORF, Verified
Description Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y' telomeric elements and subtelomeric COS genes; relocalizes to the cytosol in response to hypoxia; RGM1 has a paralog, USV1, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6, 7, 8)
Chromosomal Location
ChrXIII:625167 to 624532 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All RGM1 GO evidence and references
  View Computational GO annotations for RGM1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 40 genes
Regulators 3 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
unspecified
Resources
21 total interaction(s) for 20 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 3
  • Biochemical Activity: 2
  • Protein-peptide: 1
  • Protein-RNA: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 1
  • Negative Genetic: 6
  • Positive Genetic: 3
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 211
Molecular Weight (Da) 23,855
Isoelectric Point (pI) 10.4
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:625167 to 624532 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..636 625167..624532 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004794
References cited on this page View Complete Literature Guide for RGM1
1) Estruch F  (1991) The yeast putative transcriptional repressor RGM1 is a proline-rich zinc finger protein. Nucleic Acids Res 19(18):4873-7
2) Bohm S, et al.  (1997) Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. Nucleic Acids Res 25(12):2464-9
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Chua G, et al.  (2006) Identifying transcription factor functions and targets by phenotypic activation. Proc Natl Acad Sci U S A 103(32):12045-50
5) Mak HC, et al.  (2009) Dynamic reprogramming of transcription factors to and from the subtelomere. Genome Res 19(6):1014-25
6) Smith JJ, et al.  (2011) Environment-responsive transcription factors bind subtelomeric elements and regulate gene silencing. Mol Syst Biol 7():455
7) Joshi A, et al.  (2011) Structural and functional organization of RNA regulons in the post-transcriptional regulatory network of yeast. Nucleic Acids Res 39(21):9108-17
8) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30
9) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87