EAR1/YMR171C Summary Help

Standard Name EAR1 1
Systematic Name YMR171C
Feature Type ORF, Verified
Description Specificity factor required for Rsp5p-dependent ubiquitination; also required for sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p (1, 2, 3, 4, 5)
Name Description Endosomal Adaptor of Rsp5p 1
Chromosomal Location
ChrXIII:605520 to 603868 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All EAR1 GO evidence and references
Molecular Function
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Large-scale survey
null
overexpression
Resources
18 total interaction(s) for 10 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Biochemical Activity: 2
  • Co-localization: 1
  • Co-purification: 1
  • Protein-peptide: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 3
  • Positive Genetic: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 550
Molecular Weight (Da) 62,532
Isoelectric Point (pI) 4.5
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:605520 to 603868 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1653 605520..603868 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004781
References cited on this page View Complete Literature Guide for EAR1
1) Leon S, et al.  (2008) Ear1p and ssh4p are new adaptors of the ubiquitin ligase rsp5p for cargo ubiquitylation and sorting at multivesicular bodies. Mol Biol Cell 19(6):2379-88
2) Giaever G, et al.  (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
3) Shepard KA, et al.  (2003) Widespread cytoplasmic mRNA transport in yeast: identification of 22 bud-localized transcripts using DNA microarray analysis. Proc Natl Acad Sci U S A 100(20):11429-34
4) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
5) Terashima H, et al.  (2002) Sequence-based approach for identification of cell wall proteins in Saccharomyces cerevisiae. Curr Genet 40(5):311-6