TPP1/YMR156C Summary Help

TPP1 BASIC INFORMATION

Standard Name TPP1
Systematic Name YMR156C
Feature Type ORF, Verified
Description DNA 3'-phosphatase that functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; has similarity to the l-2-haloacid dehalogenase superfamily (1, 2)
Name Description Three Prime Phosphatase 3
GO Annotations All TPP1 GO evidence and references
    View Computational GO annotations for TPP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All TPP1 Phenotype details and references
Classical genetics
null
overexpression
Large-scale survey
null
Interactions TPP1 All interactions details and references
  View additional details at BioGRID
43 total interaction(s) for 33 unique genes/features.
Genetic Interactions
  • Negative Genetic: 10
  • Positive Genetic: 3
  • Synthetic Growth Defect: 25
  • Synthetic Lethality: 3
  • Synthetic Rescue: 2
Sequence Information
ChrXIII:571015 to 570299 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..717 571015..570299 1996-07-31 1996-07-31
Post-translational Modifications PhosphoGRID | PhosphoPep Database
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004765

TPP1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for TPP1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for TPP1]

1) Vance JR and Wilson TE  (2001) Repair of DNA strand breaks by the overlapping functions of lesion-specific and non-lesion-specific DNA 3' phosphatases. Mol Cell Biol 21(21):7191-8
2) Deshpande RA and Wilson TE  (2004) Identification of DNA 3'-phosphatase active site residues and their differential role in DNA binding, Mg2+ coordination, and catalysis. Biochemistry 43(26):8579-89
3) Vance JR and Wilson TE  (2001) Uncoupling of 3'-phosphatase and 5'-kinase functions in budding yeast. Characterization of Saccharomyces cerevisiae DNA 3'-phosphatase (TPP1). J Biol Chem 276(18):15073-81