Standard Name	RIM13 1
Systematic Name	YMR154C
Alias	CPL1
Feature Type	ORF, Verified
Description	Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB (2, 3, 4)
Name Description	Regulator of IME2 1

Chromosomal Location	ChrXIII:568182 to 565999 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for RIM13
Molecular Function
Manually curated	cysteine-type endopeptidase activity (IDA)
Biological Process
Manually curated	protein processing (IGI, IMP)
Cellular Component
Manually curated	cellular_component unknown (ND)

Classical genetics
conditional	cold sensitivity: increased
null	biofilm formation: decreased invasive growth: decreased metal resistance: increased Nrg1p-3HA accumulation: increased resistance to lithium chloride: decreased resistance to hypochlorous acid: decreased toxin resistance: decreased utilization of carbon source: decreased viability: decreased viability: increased
unspecified	sporulation efficiency: decreased transposable element transposition: decreased
Large-scale survey
null	acid pH resistance: decreased competitive fitness: decreased filamentous growth: decreased hyperosmotic stress resistance: decreased invasive growth: absent resistance to (S)-lactic acid: increased resistance to sirolimus: increased resistance to fluconazole: decreased resistance to pyrrolidine dithiocarbamate: decreased resistance to cycloheximide: decreased resistance to hydroxyurea: decreased resistance to mycophenolic acid: decreased resistance to tunicamycin: decreased resistance to BPS: decreased resistance to camptothecin: decreased sporulation efficiency: decreased stress resistance: increased toxin resistance: decreased transposable element transposition: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	246 total interaction(s) for 177 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 4 Affinity Capture-Western: 1 PCA: 2 Reconstituted Complex: 1 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 187 Phenotypic Enhancement: 1 Phenotypic Suppression: 4 Positive Genetic: 18 Synthetic Growth Defect: 17 Synthetic Lethality: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:568182 to 565999 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2184 568182..565999 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004763