TIF34/YMR146C Summary Help

Standard Name TIF34
Systematic Name YMR146C
Feature Type ORF, Verified
Description eIF3i subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; essential for translation; stimulates rate of ribosomal scanning during translation reinitiation (1, 2)
Name Description Translation Initiation Factor
Chromosomal Location
ChrXIII:558524 to 557481 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All TIF34 GO evidence and references
  View Computational GO annotations for TIF34
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Resources
Large-scale survey
null
reduction of function
unspecified
Resources
161 total interaction(s) for 62 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 74
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 35
  • Co-crystal Structure: 1
  • Co-fractionation: 11
  • Co-purification: 3
  • Protein-peptide: 4
  • Reconstituted Complex: 14
  • Two-hybrid: 9

Genetic Interactions
  • Dosage Rescue: 6

Resources
Expression Summary
histogram
Resources
Length (a.a.) 347
Molecular Weight (Da) 38,755
Isoelectric Point (pI) 5.48
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:558524 to 557481 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1044 558524..557481 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004754
References cited on this page View Complete Literature Guide for TIF34
1) Phan L, et al.  (1998) Identification of a translation initiation factor 3 (eIF3) core complex, conserved in yeast and mammals, that interacts with eIF5. Mol Cell Biol 18(8):4935-46
2) Cuchalova L, et al.  (2010) The RNA Recognition Motif of Eukaryotic Translation Initiation Factor 3g (eIF3g) Is Required for Resumption of Scanning of Posttermination Ribosomes for Reinitiation on GCN4 and Together with eIF3i Stimulates Linear Scanning. Mol Cell Biol 30(19):4671-86