SIP5/YMR140W Summary Help

Standard Name SIP5 1
Systematic Name YMR140W
Feature Type ORF, Verified
Description Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress (1, 2)
Name Description Snf1 Interacting Protein 1
Chromosomal Location
ChrXIII:547714 to 549183 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SIP5 GO evidence and references
  View Computational GO annotations for SIP5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
60 total interaction(s) for 50 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 13
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Biochemical Activity: 13
  • PCA: 3
  • Reconstituted Complex: 9
  • Two-hybrid: 3

Genetic Interactions
  • Negative Genetic: 13
  • Positive Genetic: 2
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 489
Molecular Weight (Da) 55,859
Isoelectric Point (pI) 7.79
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:547714 to 549183 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1470 547714..549183 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004748
References cited on this page View Complete Literature Guide for SIP5
1) Sanz P, et al.  (2000) Sip5 interacts with both the Reg1/Glc7 protein phosphatase and the Snf1 protein kinase of Saccharomyces cerevisiae. Genetics 154(1):99-107
2) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76