SAS2/YMR127C Summary

SAS2 BASIC INFORMATION

Standard Name	SAS2 1
Systematic Name	YMR127C
Feature Type	ORF, Verified
Description	Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family (2, 3)
Name Description	Something About Silencing 1
Gene Product Alias	KAT8 4

GO Annotations	All SAS2 GO evidence and references
	View Computational GO annotations for SAS2
Molecular Function
Manually curated	acetyltransferase activity (IDA) histone acetyltransferase activity (IDA)
Biological Process
Manually curated	chromatin silencing at telomere (IDA) histone acetylation (IMP) histone exchange (IMP)
Cellular Component
Manually curated	nuclear chromatin (IDA) nuclear chromosome, telomeric region (IC) SAS acetyltransferase complex (IDA, IPI)

Mutant Phenotype	All SAS2 Phenotype details and references
Classical genetics
null	resistance to arsenite(3-): decreased silencing: increased
Large-scale survey
null	viable
overexpression	silencing: abnormal

Interactions	SAS2 All interactions details and references
	97 total interaction(s) for 56 unique genes/features.
Physical Interactions	Affinity Capture-MS: 15 Affinity Capture-Western: 12 Co-fractionation: 2 Co-localization: 5 Reconstituted Complex: 4 Two-hybrid: 6
Genetic Interactions	Phenotypic Enhancement: 19 Phenotypic Suppression: 7 Synthetic Growth Defect: 21 Synthetic Lethality: 2 Synthetic Rescue: 4

Sequence Information

ChrXIII:523344 to 522328 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1017	523344..522328	1996-07-31	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004734

SAS2 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for SAS2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SAS2]

1)	Reifsnyder C, et al. (1996) Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases. Nat Genet 14(1):42-9
2)	Osada S, et al. (2001) The yeast SAS (something about silencing) protein complex contains a MYST-type putative acetyltransferase and functions with chromatin assembly factor ASF1. Genes Dev 15(23):3155-68
3)	Shia WJ, et al. (2005) Characterization of the yeast trimeric-SAS acetyltransferase complex. J Biol Chem 280(12):11987-94
4)	Allis CD, et al. (2007) New nomenclature for chromatin-modifying enzymes. Cell 131(4):633-6

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