STO1/YMR125W Summary Help

STO1 BASIC INFORMATION

Standard Name STO1
Systematic Name YMR125W
Alias CBC1 1 , GCR3 , CBP80 , SUT1
Feature Type ORF, Verified
Description Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80 (1, 2, 3, 4, 5, 6)
Name Description Suppressor of top1
GO Annotations All STO1 GO evidence and references
    View Computational GO annotations for STO1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All STO1 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions STO1 All interactions details and references
304 total interaction(s) for 155 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 201
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • PCA: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 1
Genetic Interactions
  • Phenotypic Enhancement: 38
  • Phenotypic Suppression: 20
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 22
  • Synthetic Rescue: 12
Sequence Information
ChrXIII:517538 to 520445 | ORF Map | GBrowse
Gbrowse
Genetic position: 87 cM
Last Update Coordinates: 1999-11-17 | Sequence: 1999-11-17
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..25 517538..517562 1999-11-17 1999-11-17
Intron 26..347 517563..517884 1999-11-17 1999-11-17
CDS 348..2908 517885..520445 1999-11-17 1999-11-17
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004732

STO1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for STO1

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
SUT1Nomenclature conflictBoth SUT1/YGL162W (a transcription factor involved in sterol transport) and STO1/YMR125W (a subunit of the nuclear cap-binding protein complex) have been referred to as "SUT1."

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for STO1]

1) Das B, et al.  (2000) The role of nuclear cap binding protein Cbc1p of yeast in mRNA termination and degradation. Mol Cell Biol 20(8):2827-38
2) Fortes P, et al.  (1999) Genetic and physical interactions involving the yeast nuclear cap-binding complex. Mol Cell Biol 19(10):6543-53
3) Lewis JD, et al.  (1996) A yeast cap binding protein complex (yCBC) acts at an early step in pre-mRNA splicing. Nucleic Acids Res 24(17):3332-6
4) Das B, et al.  (2003) Degradation of normal mRNA in the nucleus of Saccharomyces cerevisiae. Mol Cell Biol 23(16):5502-15
5) Gao Q, et al.  (2005) Cap-binding protein 1-mediated and eukaryotic translation initiation factor 4E-mediated pioneer rounds of translation in yeast. Proc Natl Acad Sci U S A 102(12):4258-63
6) Askree SH, et al.  (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63