PKR1/YMR123W Summary Help

Standard Name PKR1 1
Systematic Name YMR123W
Feature Type ORF, Verified
Description V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress (1, 2)
Name Description Pichia farinosa Killer toxin Resistance 3
Chromosomal Location
ChrXIII:513593 to 513961 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PKR1 GO evidence and references
  View Computational GO annotations for PKR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 7 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
387 total interaction(s) for 229 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Affinity Capture-RNA: 1
  • PCA: 4

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 284
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 1
  • Positive Genetic: 54
  • Synthetic Growth Defect: 27
  • Synthetic Lethality: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 122
Molecular Weight (Da) 13,962
Isoelectric Point (pI) 6.79
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:513593 to 513961 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..369 513593..513961 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004730
References cited on this page View Complete Literature Guide for PKR1
1) Davis-Kaplan SR, et al.  (2006) PKR1 encodes an assembly factor for the yeast V-type ATPase. J Biol Chem 281(42):32025-35
2) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
3) Suzuki C and Nikkuni S  (1996) Cloning of the Saccharomyces cerevisiae gene whose overexpression gives resistance against Pichia farinosa killer toxin