ADE17/YMR120C Summary

ADE17 BASIC INFORMATION

Standard Name	ADE17
Systematic Name	YMR120C
Feature Type	ORF, Verified
Description	Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade16p; ade16 ade17 mutants require adenine and histidine (1)
Name Description	ADEnine requiring

GO Annotations	All ADE17 GO evidence and references
	View Computational GO annotations for ADE17
Molecular Function
Manually curated	IMP cyclohydrolase activity (IDA) phosphoribosylaminoimidazolecarboxamide formyltransferase activity (IDA)
Biological Process
Manually curated	'de novo' IMP biosynthetic process (IDA, IMP) purine nucleotide biosynthetic process (IDA, IMP)
Cellular Component
Manually curated	cytosol (IDA)
High-throughput	plasma membrane enriched fraction (IDA)

Pathways	de novo biosynthesis of purine nucleotides superpathway of histidine, purine, and pyrimidine biosynthesis superpathway of purine biosynthesis and salvage pathways

Mutant Phenotype	All ADE17 Phenotype details and references
Classical genetics
null	resistance to cisplatin: increased
Large-scale survey
null	viable

Interactions	ADE17 All interactions details and references
	45 total interaction(s) for 39 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Biochemical Activity: 3 PCA: 24 Reconstituted Complex: 1
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 1 Phenotypic Enhancement: 2 Phenotypic Suppression: 3 Synthetic Growth Defect: 1 Synthetic Lethality: 1

Sequence Information

ChrXIII:509279 to 507501 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1779	509279..507501	1996-07-31	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004727

ADE17 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for ADE17

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ADE17]

1)	Tibbetts AS and Appling DR (2000) Characterization of two 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase isozymes from Saccharomyces cerevisiae. J Biol Chem 275(27):20920-7

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