FOL3/YMR113W Summary

FOL3 BASIC INFORMATION

Standard Name	FOL3
Systematic Name	YMR113W
Feature Type	ORF, Verified
Description	Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis (1, 2)
Name Description	FOLic acid synthesis 1

GO Annotations	All FOL3 GO evidence and references
	View Computational GO annotations for FOL3
Molecular Function
Manually curated	dihydrofolate synthase activity (IMP)
Biological Process
Manually curated	folic acid and derivative biosynthetic process (IMP)
Cellular Component
High-throughput	cytoplasm (IDA)

Pathways	folate biosynthesis pathways of chorismate superpathway of methionine biosynthesis superpathway of sulfur amino acid biosynthesis superpathway of threonine and methionine biosynthesis

Mutant Phenotype	All FOL3 Phenotype details and references
Large-scale survey
null	inviable vegetative growth: decreased

Interactions	FOL3 All interactions details and references
	4 total interaction(s) for 4 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2
Genetic Interactions	Dosage Lethality: 1 Synthetic Growth Defect: 1

Sequence Information

ChrXIII:494998 to 496281 | |

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1284	494998..496281	1996-07-31	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004719

FOL3 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for FOL3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for FOL3]

1)	Cherest H, et al. (2000) Polyglutamylation of folate coenzymes is necessary for methionine biosynthesis and maintenance of intact mitochondrial genome in Saccharomyces cerevisiae. J Biol Chem 275(19):14056-63
2)	Bayly AM, et al. (2001) Folic acid utilisation related to sulfa drug resistance in Saccharomyces cerevisiae. FEMS Microbiol Lett 204(2):387-90

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