MED11/YMR112C Summary Help

Standard Name MED11 1
Systematic Name YMR112C
Feature Type ORF, Verified
Description Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein (1, 2, 3)
Name Description MEDiator complex 1
Chromosomal Location
ChrXIII:494495 to 494100 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All MED11 GO evidence and references
  View Computational GO annotations for MED11
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Large-scale survey
null
Resources
166 total interaction(s) for 114 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 45
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 19
  • Co-crystal Structure: 1
  • Co-purification: 3
  • PCA: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 8

Genetic Interactions
  • Negative Genetic: 76
  • Positive Genetic: 9

Resources
Expression Summary
histogram
Resources
Length (a.a.) 131
Molecular Weight (Da) 15,169
Isoelectric Point (pI) 5.15
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:494495 to 494100 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..396 494495..494100 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004718
References cited on this page View Complete Literature Guide for MED11
1) Gustafsson CM, et al.  (1998) Identification of new mediator subunits in the RNA polymerase II holoenzyme from Saccharomyces cerevisiae. J Biol Chem 273(47):30851-4
2) Kornberg RD  (2005) Mediator and the mechanism of transcriptional activation. Trends Biochem Sci 30(5):235-9
3) Takagi Y, et al.  (2006) Head module control of mediator interactions. Mol Cell 23(3):355-64