ILV2/YMR108W Summary Help

Standard Name ILV2 1
Systematic Name YMR108W
Alias SMR1 , THI1
Feature Type ORF, Verified
Description Acetolactate synthase; catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control (1, 2, 3)
Name Description IsoLeucine-plus-Valine requiring 1
Chromosomal Location
ChrXIII:484084 to 486147 | ORF Map | GBrowse
Gbrowse
Genetic position: 66 cM
Gene Ontology Annotations All ILV2 GO evidence and references
  View Computational GO annotations for ILV2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 8 genes
Resources
Pathways
Classical genetics
reduction of function
Large-scale survey
null
Resources
33 total interaction(s) for 29 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 21
  • Affinity Capture-RNA: 3
  • Co-crystal Structure: 1
  • Co-purification: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 1

Genetic Interactions
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 1
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 687
Molecular Weight (Da) 74,936
Isoelectric Point (pI) 8.98
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:484084 to 486147 | ORF Map | GBrowse
SGD ORF map
Genetic position: 66 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2064 484084..486147 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004714
References cited on this page View Complete Literature Guide for ILV2
1) Falco SC, et al.  (1985) Nucleotide sequence of the yeast ILV2 gene which encodes acetolactate synthase. Nucleic Acids Res 13(11):4011-27
2) Xiao W and Rank GH  (1988) The yeast ILV2 gene is under general amino acid control. Genome 30(6):984-6
3) Kingsbury JM, et al.  (2004) Cryptococcus neoformans Ilv2p confers resistance to sulfometuron methyl and is required for survival at 37 degrees C and in vivo. Microbiology 150(Pt 5):1547-58