Standard Name	YPK2
Systematic Name	YMR104C
Alias	YKR2
Feature Type	ORF, Verified
Description	Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog, YPK1, that arose from the whole genome duplication (1, 2, 3)
Name Description	Yeast Protein Kinase

Chromosomal Location	ChrXIII:475453 to 473420 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for YPK2
Molecular Function
Manually curated	protein kinase activity (ISS)
Biological Process
Manually curated	eisosome assembly (IGI) protein phosphorylation (ISS)
Cellular Component
Manually curated	nucleus (IDA)
High-throughput	cytoplasm (IDA)

Regulatory modules	predicted: stressResponse (445)

Classical genetics
null	toxin resistance: decreased viable
Large-scale survey
null	auxotrophy competitive fitness: decreased haploinsufficient resistance to benzo[a]pyrene: increased resistance to glycolaldehyde: decreased resistance to methyl methanesulfonate: decreased vacuolar morphology: abnormal viable
overexpression	filamentous growth: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	72 total interaction(s) for 53 unique genes/features.
Physical Interactions	Affinity Capture-MS: 16 Affinity Capture-RNA: 1 Affinity Capture-Western: 6 Biochemical Activity: 3 PCA: 1 Reconstituted Complex: 2 Two-hybrid: 4
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 9 Negative Genetic: 17 Phenotypic Enhancement: 2 Phenotypic Suppression: 2 Positive Genetic: 1 Synthetic Lethality: 3 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:475453 to 473420 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2034 475453..473420 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004710