SEC14/YMR079W Summary Help

SEC14 BASIC INFORMATION

Standard Name SEC14 1
Systematic Name YMR079W
Alias PIT1 2
Feature Type ORF, Verified
Description Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; functionally homologous to mammalian PITPs (3, 4, 5)
Name Description SECretory 6
GO Annotations All SEC14 GO evidence and references
    View Computational GO annotations for SEC14
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All SEC14 Phenotype details and references
Classical genetics
conditional
null
Large-scale survey
null
overexpression
repressible
Interactions SEC14 All interactions details and references
215 total interaction(s) for 150 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-RNA: 1
  • Two-hybrid: 8
Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Rescue: 24
  • Phenotypic Enhancement: 6
  • Phenotypic Suppression: 7
  • Synthetic Growth Defect: 105
  • Synthetic Lethality: 38
  • Synthetic Rescue: 17
Sequence Information
ChrXIII:424988 to 426058 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..9 424988..424996 1996-07-31 1996-07-31
Intron 10..165 424997..425152 1996-07-31 1996-07-31
CDS 166..1071 425153..426058 1996-07-31 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004684

SEC14 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SEC14

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SEC14]

1) Novick P, et al.  (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21(1):205-15
2) Aitken JF, et al.  (1990) The gene encoding the phosphatidylinositol transfer protein is essential for cell growth. J Biol Chem 265(8):4711-7
3) Yanagisawa LL, et al.  (2002) Activity of specific lipid-regulated ADP ribosylation factor-GTPase-activating proteins is required for Sec14p-dependent Golgi secretory function in yeast. Mol Biol Cell 13(7):2193-206
4) Schnabl M, et al.  (2003) Subcellular localization of yeast Sec14 homologues and their involvement in regulation of phospholipid turnover. Eur J Biochem 270(15):3133-45
5) Mousley CJ, et al.  (2008) Trans-Golgi network and endosome dynamics connect ceramide homeostasis with regulation of the unfolded protein response and TOR signaling in yeast. Mol Biol Cell 19(11):4785-803
6) Novick P and Schekman R  (1979) Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 76(4):1858-62