MOT3/YMR070W Summary

MOT3 BASIC INFORMATION

Standard Name	MOT3 1
Systematic Name	YMR070W
Alias	ROX7
Feature Type	ORF, Verified
Description	Nuclear transcription factor with two Cys2-His2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes (2, 3, 4)
Name Description	Modifier of Transcription 1

GO Annotations	All MOT3 GO evidence and references
	View Computational GO annotations for MOT3
Molecular Function
Manually curated	DNA binding (IPI) specific transcriptional repressor activity (IGI, IMP) transcription activator activity (TAS) transcription repressor activity (IDA)
Biological Process
Manually curated	negative regulation of transcription from RNA polymerase II promoter (IGI, IMP) transcription (IGI, IMP, IPI)
Cellular Component
High-throughput	nucleus (IDA)

Regulatory Role
Binding motifs	MOT3 Transcription Factor Binding Sites and References
	HAGGYA

Mutant Phenotype	All MOT3 Phenotype details and references
Classical genetics
gain of function	resistance to Congo Red: increased resistance to Calcofluor White: increased
null	resistance to mycophenolic acid: decreased resistance to 6-azauracil: decreased
Large-scale survey
null	competitive fitness: decreased filamentous growth: increased resistance to mycophenolic acid: decreased respiratory growth: absent telomere length: decreased viable
overexpression	filamentous growth: decreased invasive growth: absent inviable

Interactions	MOT3 All interactions details and references
	28 total interaction(s) for 26 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 PCA: 2 Protein-RNA: 1 Reconstituted Complex: 1 Two-hybrid: 6
Genetic Interactions	Dosage Rescue: 4 Phenotypic Enhancement: 2 Synthetic Growth Defect: 4 Synthetic Lethality: 5

Sequence Information

ChrXIII:409153 to 410625 | |

Genetic position: 43 cM

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1473	409153..410625	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004674

MOT3 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for MOT3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MOT3]

1)	Madison JM, et al. (1998) Identification and analysis of Mot3, a zinc finger protein that binds to the retrotransposon Ty long terminal repeat (delta) in Saccharomyces cerevisiae. Mol Cell Biol 18(4):1879-90
2)	Grishin AV, et al. (1998) Mot3, a Zn finger transcription factor that modulates gene expression and attenuates mating pheromone signaling in Saccharomyces cerevisiae. Genetics 149(2):879-92
3)	Hongay C, et al. (2002) Mot3 is a transcriptional repressor of ergosterol biosynthetic genes and is required for normal vacuolar function in Saccharomyces cerevisiae. EMBO J 21(15):4114-24
4)	Sertil O, et al. (2003) Synergistic repression of anaerobic genes by Mot3 and Rox1 in Saccharomyces cerevisiae. Nucleic Acids Res 31(20):5831-7

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