AVO2/YMR068W Summary Help

Standard Name AVO2
Systematic Name YMR068W
Feature Type ORF, Verified
Description Component of a complex containing the Tor2p kinase and other proteins; complex may have a role in regulation of cell growth (1 and see Summary Paragraph)
Name Description Adheres VOraciously (to TOR2)
Chromosomal Location
ChrXIII:406304 to 407584 | ORF Map | GBrowse
Gene Ontology Annotations All AVO2 GO evidence and references
  View Computational GO annotations for AVO2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Classical genetics
Large-scale survey
76 total interaction(s) for 50 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 13
  • Biochemical Activity: 2
  • Reconstituted Complex: 4
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 42
  • Positive Genetic: 2
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1

Expression Summary
Length (a.a.) 426
Molecular Weight (Da) 47,139
Isoelectric Point (pI) 10.1
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXIII:406304 to 407584 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1281 406304..407584 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004672

AVO2 encodes a nonessential protein that is a subunit of the TOR complex 2 (TORC2) (2). TORC2 is involved in regulating actin cytoskeleton polarization during cell cycle progression, cell wall integrity, and nutrient receptor endocytosis (3, 4). In addition to Avo2p, TORC2 contains Avo1p, Tsc11, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p (1, 5, 6). Through direct physical interaction with Avo2p and Bit61p, the subunits Slm1p and Slm2p are able to associate with TORC2 (6). TORC2 is structurally conserved in higher eukaryotes and, like yeast TORC2, functions to regulate the actin cytoskeleton (1, 7).

Last updated: 2005-11-08 Contact SGD

References cited on this page View Complete Literature Guide for AVO2
1) Loewith R, et al.  (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 10(3):457-68
2) Wullschleger S, et al.  (2005) Molecular organization of target of rapamycin complex 2. J Biol Chem 280(35):30697-704
3) Schmidt A, et al.  (1996) TOR2 is required for organization of the actin cytoskeleton in yeast. Proc Natl Acad Sci U S A 93(24):13780-5
4) deHart AK, et al.  (2003) Receptor internalization in yeast requires the Tor2-Rho1 signaling pathway. Mol Biol Cell 14(11):4676-84
5) Reinke A, et al.  (2004) TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae. J Biol Chem 279(15):14752-62
6) Fadri M, et al.  (2005) The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2. Mol Biol Cell 16(4):1883-900
7) Jacinto E, et al.  (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 6(11):1122-8