ARG7/YMR062C Summary Help

Standard Name ARG7 1
Systematic Name YMR062C
Alias ECM40 2
Feature Type ORF, Verified
Description Mitochondrial ornithine acetyltransferase; catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine (1 and see Summary Paragraph)
Name Description ARGinine requiring
Chromosomal Location
ChrXIII:396379 to 395054 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ARG7 GO evidence and references
  View Computational GO annotations for ARG7
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 7 genes
Resources
Pathways
Classical genetics
null
Large-scale survey
null
unspecified
Resources
54 total interaction(s) for 53 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1

Genetic Interactions
  • Negative Genetic: 23
  • Positive Genetic: 25
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 441
Molecular Weight (Da) 47,848
Isoelectric Point (pI) 7.1
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:396379 to 395054 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1326 396379..395054 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004666
SUMMARY PARAGRAPH for ARG7

ARG7 encodes the mitochondrial matrix enzyme glutamate N-acetyltransferase (also called ornithine acetyltransferase) (1, 3), which catalyzes the fifth step in the biosynthesis of ornithine, an intermediate in arginine biosynthesis (4). Deletion of ARG7 causes a leaky Arg- phenotype, suggesting that yeast cells can generate ornithine from acetylornithine by an alternative route (1). ARG7p also has amino-acid N-acetyltransferase activity (1), and shows sequence similarity to glutamate N-acetyltransferases from several bacterial species (1). ARG7 was identified in a large-scale screen for mutants affecting cell surface assembly (2).

Last updated: 1999-10-21 Contact SGD

References cited on this page View Complete Literature Guide for ARG7
1) Crabeel M, et al.  (1997) Characterization of the Saccharomyces cerevisiae ARG7 gene encoding ornithine acetyltransferase, an enzyme also endowed with acetylglutamate synthase activity. Eur J Biochem 250(2):232-41
2) Lussier M, et al.  (1997) Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae. Genetics 147(2):435-50
3) Liu Y, et al.  (1995) Purification and characterization of ornithine acetyltransferase from Saccharomyces cerevisiae. Eur J Biochem 228(2):291-6
4) Jauniaux JC, et al.  (1978) Arginine metabolism in Saccharomyces cerevisiae: subcellular localization of the enzymes. J Bacteriol 133(3):1096-1107