Standard Name	RNA14
Systematic Name	YMR061W
Feature Type	ORF, Verified
Description	Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping (1, 2, 3, 4, 5)
Name Description	RNA synthesis

Chromosomal Location	ChrXIII:392755 to 394788 | ORF Map | GBrowse

	View Computational GO annotations for RNA14
Molecular Function
Manually curated	protein heterodimerization activity (IPI) contributes_to RNA binding (IDA)
Biological Process
Manually curated	mRNA cleavage (IDA) mRNA polyadenylation (IDA)
Cellular Component
Manually curated	mitochondrion (IDA) mRNA cleavage factor complex (IPI) nucleus (IDA)

Classical genetics
conditional	3' extended forms of NAB2 mRNA accumulation: increased poly(A)+ RNA accumulation: decreased heat sensitivity: increased snoRNP distribution: abnormal U14 snoRNA distribution: abnormal resistance to cordycepin: decreased vegetative growth: decreased
Large-scale survey
conditional	heat sensitivity: increased
null	competitive fitness: decreased haploinsufficient inviable resistance to sodium arsenite: decreased
overexpression	vegetative growth: decreased rate
reduction of function	competitive fitness: decreased telomere length: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	192 total interaction(s) for 92 unique genes/features.
Physical Interactions	Affinity Capture-MS: 74 Affinity Capture-RNA: 3 Affinity Capture-Western: 16 Co-crystal Structure: 1 Co-fractionation: 2 Co-purification: 1 Far Western: 1 Reconstituted Complex: 11 Two-hybrid: 14
Genetic Interactions	Dosage Rescue: 4 Negative Genetic: 10 Phenotypic Suppression: 3 Positive Genetic: 8 Synthetic Growth Defect: 19 Synthetic Lethality: 19 Synthetic Rescue: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:392755 to 394788 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2034 392755..394788 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004665