Standard Name	CSM3 1
Systematic Name	YMR048W
Feature Type	ORF, Verified
Description	Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress (1, 2, 3, 4, 5)
Name Description	Chromosome Segregation in Meiosis 1

Chromosomal Location	ChrXIII:366981 to 367934 | ORF Map | GBrowse

	View Computational GO annotations for CSM3
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	DNA repair (IGI, IMP) DNA replication checkpoint (IGI) establishment of mitotic sister chromatid cohesion (IGI, IMP) maintenance of DNA repeat elements (IMP) meiotic chromosome segregation (IMP) mitotic sister chromatid cohesion (IGI, IMP) replication fork arrest (IMP) replication fork protection (IMP)
Cellular Component
Manually curated	replication fork protection complex (IDA)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Classical genetics
null	UV resistance: decreased chromosome/plasmid maintenance: abnormal colony sectoring: increased prion formation: decreased Smc3p modification: decreased resistance to selenomethionine: decreased resistance to benomyl: decreased resistance to camptothecin: decreased resistance to bortezomib: decreased resistance to selenite(2-): decreased resistance to hydroxyurea: decreased
Large-scale survey
null	competitive fitness: decreased haploproficient meiosis: abnormal resistance to methyl methanesulfonate: decreased resistance to hydroxyurea: decreased resistance to camptothecin: decreased resistance to bleomycin: decreased resistance to fluconazole: increased resistance to caffeine: increased resistance to cycloheximide: increased resistance to sodium selenide: decreased spore germination: decreased transposable element transposition: increased viable
overexpression	resistance to sirolimus: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	471 total interaction(s) for 216 unique genes/features.
Physical Interactions	Affinity Capture-MS: 19 Affinity Capture-RNA: 1 Affinity Capture-Western: 19 Biochemical Activity: 1 Reconstituted Complex: 3 Two-hybrid: 8
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 1 Negative Genetic: 167 Phenotypic Enhancement: 11 Phenotypic Suppression: 7 Positive Genetic: 10 Synthetic Growth Defect: 161 Synthetic Lethality: 60 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:366981 to 367934 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..954 366981..367934 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004651