IOC4/YMR044W Summary Help

Standard Name IOC4 1
Systematic Name YMR044W
Feature Type ORF, Verified
Description Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing (1, 2, 3)
Name Description Iswi One Complex 1
Chromosomal Location
ChrXIII:355384 to 356811 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All IOC4 GO evidence and references
  View Computational GO annotations for IOC4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
134 total interaction(s) for 104 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 10
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 4
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 105
  • Positive Genetic: 10

Resources
Expression Summary
histogram
Resources
Length (a.a.) 475
Molecular Weight (Da) 55,426
Isoelectric Point (pI) 5.05
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:355384 to 356811 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1428 355384..356811 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004647
References cited on this page View Complete Literature Guide for IOC4
1) Vary JC Jr, et al.  (2003) Yeast Isw1p forms two separable complexes in vivo. Mol Cell Biol 23(1):80-91
2) Morillon A, et al.  (2003) Isw1 chromatin remodeling ATPase coordinates transcription elongation and termination by RNA polymerase II. Cell 115(4):425-35
3) Smolle M, et al.  (2012) Chromatin remodelers Isw1 and Chd1 maintain chromatin structure during transcription by preventing histone exchange. Nat Struct Mol Biol 19(9):884-92