Standard Name	CCS1
Systematic Name	YMR038C
Alias	LYS7
Feature Type	ORF, Verified
Description	Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress (1, 2, 3) Also known as: CCS
Name Description	Copper Chaperone for SOD1 4

Chromosomal Location	ChrXIII:348260 to 347511 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 30 cM

	View Computational GO annotations for CCS1
Molecular Function
Manually curated	superoxide dismutase copper chaperone activity (IGI, IMP, ISS)
Biological Process
Manually curated	intracellular copper ion transport (IMP, ISS)
Cellular Component
Manually curated	cytosol (IDA) mitochondrial inner membrane (IDA) nucleus (IDA)

Classical genetics
null	alkaline pH resistance: decreased auxotrophy resistance to tunicamycin: normal resistance to paraquat: normal resistance to paraquat: decreased resistance to tunicamycin: decreased resistance to 1-O-hexadecyl-2-acetyl-sn-glycerophosphocholine: decreased respiratory growth: absent
Large-scale survey
null	alkaline pH resistance: decreased competitive fitness: decreased endocytosis: decreased heat sensitivity: increased oxidative stress resistance: decreased resistance to hydrogen chloride: decreased resistance to acetic acid: decreased resistance to (S)-lactic acid: decreased resistance to tunicamycin: decreased resistance to hydroxyurea: decreased resistance to ethanol: decreased resistance to tirapazamine: decreased resistance to CTBT: decreased resistance to propan-1-ol: decreased resistance to methanol: decreased resistance to methyl methanesulfonate: decreased resistance to doxorubicin: decreased resistance to fluconazole: increased resistance to caffeine: increased resistance to cycloheximide: increased resistance to bleomycin: increased resistance to wortmannin: increased resistance to sirolimus: increased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to cadmium dichloride: decreased resistance to sodium arsenite: decreased resistance to camptothecin: decreased resistance to dimethyl sulfoxide: decreased resistance to 5-fluorouracil: decreased resistance to L-1,4-dithiothreitol: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	255 total interaction(s) for 177 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Co-crystal Structure: 2 Co-purification: 1 Reconstituted Complex: 2 Two-hybrid: 2
Genetic Interactions	Negative Genetic: 85 Phenotypic Enhancement: 1 Positive Genetic: 16 Synthetic Growth Defect: 99 Synthetic Lethality: 41 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:348260 to 347511 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 30 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..750 348260..347511 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004641