CCS1/YMR038C Summary

CCS1 BASIC INFORMATION

Standard Name	CCS1
Systematic Name	YMR038C
Alias	LYS7
Feature Type	ORF, Verified
Description	Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation (1, 2) Also known as: CCS
Name Description	Copper Chaperone for SOD1 3

GO Annotations	All CCS1 GO evidence and references
	View Computational GO annotations for CCS1
Molecular Function
Manually curated	superoxide dismutase copper chaperone activity (IGI, IMP, ISS)
Biological Process
Manually curated	intracellular copper ion transport (IMP, ISS)
Cellular Component
Manually curated	cytosol (IDA) mitochondrial inner membrane (IDA) nucleus (IDA)

Mutant Phenotype	All CCS1 Phenotype details and references
Classical genetics
null	alkaline pH resistance: decreased auxotrophy resistance to paraquat: decreased resistance to paraquat: normal resistance to tunicamycin: normal resistance to tunicamycin: decreased respiratory growth: absent
Large-scale survey
null	alkaline pH resistance: decreased competitive fitness: decreased oxidative stress resistance: decreased resistance to rapamycin: increased resistance to wortmannin: increased resistance to cadmium dichloride: decreased resistance to doxorubicin: decreased resistance to ethanol: decreased resistance to 5-fluorouracil: decreased resistance to L-1,4-dithiothreitol: decreased resistance to tunicamycin: decreased resistance to methyl methanesulfonate: decreased resistance to methanol: decreased resistance to propan-1-ol: decreased viable

Interactions	CCS1 All interactions details and references
	241 total interaction(s) for 166 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Co-crystal Structure: 2 Co-purification: 1 Reconstituted Complex: 1 Two-hybrid: 2
Genetic Interactions	Phenotypic Enhancement: 75 Phenotypic Suppression: 16 Synthetic Growth Defect: 94 Synthetic Lethality: 45

Sequence Information

ChrXIII:348259 to 347510 | |

Note: this feature is encoded on the Crick strand.

Genetic position: 30 cM

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..750	348259..347510	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004641

CCS1 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CCS1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CCS1]

1)	Schmidt PJ, et al. (1999) A gain of superoxide dismutase (SOD) activity obtained with CCS, the copper metallochaperone for SOD1. J Biol Chem 274(52):36952-6
2)	Brown NM, et al. (2004) Oxygen and the copper chaperone CCS regulate posttranslational activation of Cu,Zn superoxide dismutase. Proc Natl Acad Sci U S A 101(15):5518-23
3)	Lamb AL, et al. (2000) Heterodimer formation between superoxide dismutase and its copper chaperone. Biochemistry 39(48):14720-7

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.