HOF1/YMR032W Summary Help

HOF1 BASIC INFORMATION

Standard Name HOF1
Systematic Name YMR032W
Alias CYK2
Feature Type ORF, Verified
Description Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p (1, 2, 3, 4, 5)
Name Description Homolog Of cdc Fifteen 1
GO Annotations All HOF1 GO evidence and references
    View Computational GO annotations for HOF1
Molecular Function
Manually curated
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
Mutant Phenotype All HOF1 Phenotype details and references
Classical genetics
unspecified
Large-scale survey
null
overexpression
Interactions HOF1 All interactions details and references
85 total interaction(s) for 55 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-Western: 2
  • Co-localization: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 63
Genetic Interactions
  • Dosage Rescue: 2
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 2
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 7
Sequence Information
ChrXIII:335297 to 337306 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2010 335297..337306 1996-07-31 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004635

HOF1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Protein Info & Structure
  • Localization Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for HOF1

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
CDC15Nomenclature conflictCDC15/YAR019C encodes a protein kinase involved in exit from mitosis. Do not confuse CDC15/YAR019C with pombe cdc15, which is similar to the cerevisiae HOF1/YMR032W gene.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HOF1]

1) Kamei T, et al.  (1998) Interaction of Bnr1p with a novel Src homology 3 domain-containing Hof1p. Implication in cytokinesis in Saccharomyces cerevisiae. J Biol Chem 273(43):28341-5
2) Lippincott J and Li R  (1998) Dual function of Cyk2, a cdc15/PSTPIP family protein, in regulating actomyosin ring dynamics and septin distribution. J Cell Biol 143(7):1947-60
3) Korinek WS, et al.  (2000) Cyk3, a novel SH3-domain protein, affects cytokinesis in yeast. Curr Biol 10(15):947-50
4) Naqvi SN, et al.  (2001) Vrp1p functions in both actomyosin ring-dependent and Hof1p-dependent pathways of cytokinesis. Traffic 2(3):189-201
5) Lee PR, et al.  (2002) Bni5p, a septin-interacting protein, is required for normal septin function and cytokinesis in Saccharomyces cerevisiae. Mol Cell Biol 22(19):6906-20