CSI1/YMR025W Summary

CSI1 BASIC INFORMATION

Standard Name	CSI1
Systematic Name	YMR025W
Feature Type	ORF, Verified
Description	Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling (1, 2)
Name Description	Cop9 Signalosome Interactor 2

GO Annotations	All CSI1 GO evidence and references
	View Computational GO annotations for CSI1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	adaptation to pheromone during conjugation with cellular fusion (IMP) cullin deneddylation (IMP)
Cellular Component
Manually curated	signalosome (IDA)

Mutant Phenotype	All CSI1 Phenotype details and references
Classical genetics
null	mating efficiency: decreased Cdc53p modification: increased recovery from pheromone-induced cell cycle arrest: increased shmoo formation: decreased rate toxin resistance: increased
Large-scale survey
null	UV resistance: decreased viable

Interactions	CSI1 All interactions details and references
	43 total interaction(s) for 27 unique genes/features.
Physical Interactions	Affinity Capture-MS: 11 Affinity Capture-RNA: 1 Two-hybrid: 13
Genetic Interactions	Phenotypic Suppression: 17 Synthetic Rescue: 1

Sequence Information

ChrXIII:323299 to 324186 | |

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..888	323299..324186	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004627

CSI1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CSI1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CSI1]

1)	Wee S, et al. (2002) Conservation of the COP9/signalosome in budding yeast. BMC Genet 3():15
2)	Maytal-Kivity V, et al. (2002) COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae. EMBO Rep 3(12):1215-21

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