Standard Name	UBC7 1
Systematic Name	YMR022W
Alias	QRI8 2 , DER2 3
Feature Type	ORF, Verified
Description	Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly (4, 5)
Name Description	UBiquitin-Conjugating enzyme 1

Chromosomal Location	ChrXIII:318680 to 319177 | ORF Map | GBrowse

	View Computational GO annotations for UBC7
Molecular Function
Manually curated	ubiquitin-protein ligase activity (IDA, ISS)
Biological Process
Manually curated	chromatin assembly or disassembly (IMP) ER-associated protein catabolic process (IDA, IGI, IMP) fungal-type cell wall organization (IGI)
Cellular Component
Manually curated	endoplasmic reticulum membrane (IDA)

Classical genetics
null	metal resistance: decreased CPY* accumulation: increased Ura3p-CL1 accumulation: increased resistance to cadmium dichloride: decreased toxin resistance: decreased
overexpression	metal resistance: increased
Large-scale survey
null	anaerobic growth: decreased bud morphology: abnormal competitive fitness: increased haploinsufficient metal resistance: decreased resistance to methyl methanesulfonate: decreased resistance to camptothecin: decreased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to bleomycin: decreased resistance to fenpropimorph: increased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	317 total interaction(s) for 164 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-RNA: 3 Affinity Capture-Western: 7 Biochemical Activity: 1 Co-purification: 1 Reconstituted Complex: 4
Genetic Interactions	Dosage Growth Defect: 2 Dosage Lethality: 2 Dosage Rescue: 1 Negative Genetic: 153 Phenotypic Enhancement: 32 Phenotypic Suppression: 27 Positive Genetic: 57 Synthetic Growth Defect: 9 Synthetic Lethality: 5 Synthetic Rescue: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:318680 to 319177 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..498 318680..319177 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004624