FMS1/YMR020W Summary Help

Standard Name FMS1
Systematic Name YMR020W
Feature Type ORF, Verified
Description Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis (1, 2, 3)
Name Description Fenpropimorph-resistance Multicopy Suppressor
Chromosomal Location
ChrXIII:315377 to 316903 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All FMS1 GO evidence and references
  View Computational GO annotations for FMS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 1 genes
Resources
Pathways
Classical genetics
null
Large-scale survey
null
overexpression
Resources
42 total interaction(s) for 35 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1

Genetic Interactions
  • Negative Genetic: 27
  • Phenotypic Enhancement: 1
  • Positive Genetic: 11
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 508
Molecular Weight (Da) 57,805
Isoelectric Point (pI) 5.45
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:315377 to 316903 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1527 315377..316903 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004622
References cited on this page View Complete Literature Guide for FMS1
1) White WH, et al.  (2001) Saccharomyces cerevisiae is capable of de Novo pantothenic acid biosynthesis involving a novel pathway of beta-alanine production from spermine. J Biol Chem 276(14):10794-800
2) Landry J and Sternglanz R  (2003) Yeast Fms1 is a FAD-utilizing polyamine oxidase. Biochem Biophys Res Commun 303(3):771-6
3) Chattopadhyay MK, et al.  (2003) Spermidine but not spermine is essential for hypusine biosynthesis and growth in Saccharomyces cerevisiae: spermine is converted to spermidine in vivo by the FMS1-amine oxidase. Proc Natl Acad Sci U S A 100(24):13869-74