SOK2/YMR016C Summary Help

SOK2 BASIC INFORMATION

Standard Name SOK2
Systematic Name YMR016C
Feature Type ORF, Verified
Description Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors (1, 2)
Name Description Suppressor Of Kinase 3
GO Annotations All SOK2 GO evidence and references
    View Computational GO annotations for SOK2
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
High-throughput
Regulatory Role
Binding motifs SOK2 Transcription Factor Binding Sites and References
  • TGCAGNNA
Mutant Phenotype All SOK2 Phenotype details and references
Classical genetics
overexpression
Large-scale survey
null
overexpression
Interactions SOK2 All interactions details and references
15 total interaction(s) for 13 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-Western: 2
  • PCA: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 2
Genetic Interactions
  • Dosage Rescue: 1
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 1
Sequence Information
ChrXIII:305592 to 303235 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2358 305592..303235 1996-07-31 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004618

SOK2 RESOURCES

Click on map for expanded view
SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SOK2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SOK2]

1) Ward MP, et al.  (1995) SOK2 may regulate cyclic AMP-dependent protein kinase-stimulated growth and pseudohyphal development by repressing transcription. Mol Cell Biol 15(12):6854-63
2) Pan X and Heitman J  (2000) Sok2 regulates yeast pseudohyphal differentiation via a transcription factor cascade that regulates cell-cell adhesion. Mol Cell Biol 20(22):8364-72
3) Ward MP and Garrett S  (1994) Suppression of a yeast cyclic AMP-dependent protein kinase defect by overexpression of SOK1, a yeast gene exhibiting sequence similarity to a developmentally regulated mouse gene. Mol Cell Biol 14(9):5619-27