Standard Name	SOK2
Systematic Name	YMR016C
Feature Type	ORF, Verified
Description	Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; SOK2 has a paralog, PHD1, that arose from the whole genome duplication (1, 2, 3)
Name Description	Suppressor Of Kinase 4

Chromosomal Location	ChrXIII:305593 to 303236 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SOK2
Molecular Function
Manually curated	sequence-specific DNA binding transcription factor activity (ISS)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	pseudohyphal growth (IMP)
Cellular Component
High-throughput	nucleus (IDA)

Binding motifs	Predicted SOK2 Binding Site Locations
	BMTGCAK 5 [Search intergenic regions for BMTGCAK] TGCAGNNA 6 [Search intergenic regions for TGCAGNNA]
Resources	ScerTF | YEASTRACT | YeTFaSCo

Classical genetics
overexpression	cell cycle progression in G1 phase: abnormal cellular morphology: abnormal
Large-scale survey
null	UV resistance: decreased auxotrophy competitive fitness: decreased filamentous growth: increased haploinsufficient hyperosmotic stress resistance: decreased resistance to citric acid: decreased resistance to ethanol: decreased resistance to cycloheximide: decreased sporulation efficiency: increased stress resistance: decreased viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	129 total interaction(s) for 120 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-Western: 2 PCA: 1 Reconstituted Complex: 1 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 86 Phenotypic Suppression: 7 Positive Genetic: 14 Synthetic Growth Defect: 7 Synthetic Lethality: 3 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:305593 to 303236 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2358 305593..303236 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004618