CLU1/YMR012W Summary Help

Standard Name CLU1 1
Systematic Name YMR012W
Alias TIF31
Feature Type ORF, Verified
Description Subunit of the eukaryotic translation initiation factor 3 (eIF3); component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation; can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant (2, 3)
Name Description CLUstered mitochondria 1
Chromosomal Location
ChrXIII:291134 to 294967 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CLU1 GO evidence and references
  View Computational GO annotations for CLU1
Molecular Function
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Large-scale survey
null
unspecified
Resources
118 total interaction(s) for 101 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 93
  • Affinity Capture-RNA: 3
  • Reconstituted Complex: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 8
  • Phenotypic Suppression: 3
  • Positive Genetic: 7
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,277
Molecular Weight (Da) 145,164
Isoelectric Point (pI) 6.36
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:291134 to 294967 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3834 291134..294967 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004614
References cited on this page View Complete Literature Guide for CLU1
1) Zhu Q, et al.  (1997) The cluA- mutant of Dictyostelium identifies a novel class of proteins required for dispersion of mitochondria. Proc Natl Acad Sci U S A 94(14):7308-13
2) Vornlocher HP, et al.  (1999) A 110-kilodalton subunit of translation initiation factor eIF3 and an associated 135-kilodalton protein are encoded by the Saccharomyces cerevisiae TIF32 and TIF31 genes. J Biol Chem 274(24):16802-12
3) Fields SD, et al.  (1998) The S. cerevisiae CLU1 and D. discoideum cluA genes are functional homologues that influence mitochondrial morphology and distribution. J Cell Sci 111 ( Pt 12):1717-27