PLB2/YMR006C Summary Help

Standard Name PLB2 1
Systematic Name YMR006C
Feature Type ORF, Verified
Description Phospholipase B (lysophospholipase) involved in lipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine (1, 2, 3)
Name Description PhosphoLipase B 1
Chromosomal Location
ChrXIII:279681 to 277561 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PLB2 GO evidence and references
  View Computational GO annotations for PLB2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 12 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
56 total interaction(s) for 54 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Co-purification: 1

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 2
  • Negative Genetic: 28
  • Phenotypic Enhancement: 1
  • Positive Genetic: 22

Resources
Expression Summary
histogram
Resources
Length (a.a.) 706
Molecular Weight (Da) 75,455
Isoelectric Point (pI) 4.35
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:279681 to 277561 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2121 279681..277561 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004608
References cited on this page View Complete Literature Guide for PLB2
1) Fyrst H, et al.  (1999) The PLB2 gene of Saccharomyces cerevisiae confers resistance to lysophosphatidylcholine and encodes a phospholipase B/lysophospholipase. Biochemistry 38(18):5864-71
2) Merkel O, et al.  (1999) Characterization and function in vivo of two novel phospholipases B/lysophospholipases from Saccharomyces cerevisiae. J Biol Chem 274(40):28121-7
3) Merkel O, et al.  (2005) Regulation of activity in vitro and in vivo of three phospholipases B from Saccharomyces cerevisiae. Biochem J 387(Pt 2):489-96