Standard Name	CDC5 1 (see Nomenclature conflict Note)
Systematic Name	YMR001C
Alias	MSD2 2 , PKX2
Feature Type	ORF, Verified
Description	Polo-like kinase with multiple functions in mitosis and cytokinesis through substrate phosphorylation, also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate (3, 4, 5, 6)
Name Description	Cell Division Cycle 7

Chromosomal Location	ChrXIII:271136 to 269019 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -14 cM

	View Computational GO annotations for CDC5
Molecular Function
Manually curated	protein kinase activity (IDA, IMP)
High-throughput	protein kinase activity (IDA)
Biological Process
Manually curated	positive regulation of spindle pole body separation (IGI, IMP) protein phosphorylation (IDA, IMP) resolution of meiotic recombination intermediates (IMP) spindle assembly involved in meiosis (IMP) synaptonemal complex disassembly (IGI)
High-throughput	protein phosphorylation (IDA)
Cellular Component
Manually curated	cellular bud neck (IDA) nucleus (IDA) spindle pole (IDA)

Regulatory modules	predicted: stressResponse (511) predicted: cellcycle (263, 221) predicted: stressResponse (511) predicted: cellcycle (263, 221)

Classical genetics
conditional	cell cycle progression: arrested cellular morphology: abnormal heat sensitivity: increased Inn1p-GFP distribution: abnormal
null	inviable
overexpression	actin cytoskeleton morphology: abnormal bipolar budding pattern: increased cell cycle progression: abnormal cell cycle progression in G2 phase: abnormal cell size: increased cellular morphology: abnormal nuclear morphology: abnormal
reduction of function	meiosis: abnormal Rec8p distribution: abnormal Zip1p distribution: abnormal Lrs4p distribution: abnormal Mam1p distribution: abnormal
repressible	cell cycle progression through the G2/M phase transition: arrested vegetative growth: decreased
Large-scale survey
null	haploproficient inviable
overexpression	inviable resistance to sirolimus: increased vegetative growth: decreased rate
reduction of function	competitive fitness: decreased resistance to hydroxyurea: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	341 total interaction(s) for 170 unique genes/features.
Physical Interactions	Affinity Capture-MS: 59 Affinity Capture-Western: 29 Biochemical Activity: 45 Co-localization: 7 Co-purification: 2 Protein-peptide: 2 Reconstituted Complex: 9 Two-hybrid: 22
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 13 Dosage Rescue: 34 Negative Genetic: 13 Phenotypic Enhancement: 14 Phenotypic Suppression: 21 Positive Genetic: 7 Synthetic Growth Defect: 10 Synthetic Lethality: 19 Synthetic Rescue: 34
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:271136 to 269019 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -14 cM
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2118 271136..269019 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004603