CDC5/YMR001C Summary Help

CDC5 BASIC INFORMATION

Standard Name CDC5 1
Systematic Name YMR001C
Alias MSD2 2 , PKX2
Feature Type ORF, Verified
Description Polo-like kinase with similarity to Xenopus Plx1 and S. pombe Plo1p; found at bud neck, nucleus and SPBs; has multiple functions in mitosis and cytokinesis through phosphorylation of substrates; may be a Cdc28p substrate (3, 4, 5)
Name Description Cell Division Cycle 6
GO Annotations All CDC5 GO evidence and references
    View Computational GO annotations for CDC5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulatory Role
Regulatory modules predicted: stressResponse ( 511 )
predicted: cellcycle ( 263 , 221 )
predicted: stressResponse ( 511 )
predicted: cellcycle ( 263 , 221 )
Mutant Phenotype All CDC5 Phenotype details and references
Classical genetics
conditional
null
overexpression
reduction of function
repressible
Large-scale survey
null
overexpression
Interactions CDC5 All interactions details and references
266 total interaction(s) for 156 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 51
  • Affinity Capture-Western: 22
  • Biochemical Activity: 40
  • Co-localization: 6
  • Reconstituted Complex: 4
  • Two-hybrid: 17
Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 12
  • Dosage Rescue: 35
  • Phenotypic Enhancement: 25
  • Phenotypic Suppression: 15
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 16
  • Synthetic Rescue: 19
Sequence Information
ChrXIII:271136 to 269019 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: -14 cM
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2118 271136..269019 1996-07-31 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004603

CDC5 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for CDC5

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
CEF1Nomenclature conflictCEF1/YMR213W encodes a splicing factor and is homologous to the pombe cdc5 gene. Do not confuse CEF1/YMR213W with cerevisiae CDC5/YMR001C, which encodes a Polo-like kinase homologous to the pombe plo1 gene.
HDA3Nomenclature conflictCDC5/YMR001C encodes a Polo-like kinase and is homologous to the pombe plo1 gene. Do not confuse CDC5/YMR001C with the cerevisiae HDA3 gene, which has been referred to in the cerevisiae literature as PLO1.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CDC5]

1) Hartwell LH, et al.  (1973) Genetic Control of the Cell Division Cycle in Yeast: V. Genetic Analysis of cdc Mutants. Genetics 74(2):267-286
2) Kitada K, et al.  (1993) A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5. Mol Cell Biol 13(7):4445-57
3) Hu F and Elledge SJ  (2002) Bub2 is a cell cycle regulated phospho-protein controlled by multiple checkpoints. Cell Cycle 1(5):351-5
4) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
5) Alexandru G, et al.  (2001) Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast. Cell 105(4):459-72
6) Hartwell LH, et al.  (1970) Genetic control of the cell-division cycle in yeast. I. Detection of mutants. Proc Natl Acad Sci U S A 66(2):352-9