ERG13/YML126C Summary Help

Standard Name ERG13 1
Systematic Name YML126C
Alias HMGS
Feature Type ORF, Verified
Description 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase; catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis (2, 3 and see Summary Paragraph)
Name Description ERGosterol biosynthesis 1
Chromosomal Location
ChrXIII:20535 to 19060 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ERG13 GO evidence and references
  View Computational GO annotations for ERG13
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 9 genes
Resources
Pathways
Classical genetics
overexpression
unspecified
Large-scale survey
conditional
null
overexpression
reduction of function
repressible
Resources
83 total interaction(s) for 69 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 33
  • Co-purification: 1
  • PCA: 3

Genetic Interactions
  • Negative Genetic: 29
  • Positive Genetic: 15
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 491
Molecular Weight (Da) 55,013
Isoelectric Point (pI) 8.23
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:20535 to 19060 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1476 20535..19060 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004595
SUMMARY PARAGRAPH for ERG13

ERG13 encodes hydroxymethylglutaryl-CoA synthase, which catalyzes the formation of hydroxymethylglutaryl-CoA (HMG-CoA) from acteyl-CoA and acetoacetyl-CoA (3). HMG-CoA formation is the second step in the biosynthesis of mevalonate, which is required in turn for the biosynthesis of sterols and nonsterol isoprenoids (4); in yeast, ergosterol is the end product of the sterol biosynthetic pathway (3, 2).

Last updated: 2000-08-21 Contact SGD

References cited on this page View Complete Literature Guide for ERG13
1) Barker KS, et al.  (2003) Identification of genes differentially expressed in association with reduced azole susceptibility in Saccharomyces cerevisiae. J Antimicrob Chemother 51(5):1131-40
2) Parks LW, et al.  (1995) Biochemical and physiological effects of sterol alterations in yeast--a review. Lipids 30(3):227-30
3) Paltauf F, et al.  (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
4) Stryer L  (1995) Biochemistry (4th ed.). New York: W. H. Freeman and Company