GTR1/YML121W Summary Help

Standard Name GTR1 1
Systematic Name YML121W
Feature Type ORF, Verified
Description Cytoplasmic GTPase; forms a heterodimer with Gtr2p to stimulate TORC1 in response to amino acids; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB (1, 2, 3, 4, 5, 6, 7, 8)
Name Description GTp binding protein Resemblance 1
Chromosomal Location
ChrXIII:26930 to 27862 | ORF Map | GBrowse
Genetic position: -99.6 cM
Gene Ontology Annotations All GTR1 GO evidence and references
  View Computational GO annotations for GTR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 8 genes
Classical genetics
Large-scale survey
272 total interaction(s) for 191 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 17
  • Affinity Capture-RNA: 5
  • Affinity Capture-Western: 14
  • Biochemical Activity: 1
  • Co-crystal Structure: 1
  • Co-fractionation: 2
  • PCA: 11
  • Reconstituted Complex: 15
  • Two-hybrid: 10

Genetic Interactions
  • Dosage Rescue: 4
  • Negative Genetic: 96
  • Phenotypic Enhancement: 7
  • Phenotypic Suppression: 42
  • Positive Genetic: 28
  • Synthetic Growth Defect: 8
  • Synthetic Lethality: 3
  • Synthetic Rescue: 8

Expression Summary
Length (a.a.) 310
Molecular Weight (Da) 35,847
Isoelectric Point (pI) 8.34
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXIII:26930 to 27862 | ORF Map | GBrowse
Genetic position: -99.6 cM
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..933 26930..27862 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004590
References cited on this page View Complete Literature Guide for GTR1
1) Bun-Ya M, et al.  (1992) Putative GTP-binding protein, Gtr1, associated with the function of the Pho84 inorganic phosphate transporter in Saccharomyces cerevisiae. Mol Cell Biol 12(7):2958-66
2) Nakashima N, et al.  (1996) Putative GTPase Gtr1p genetically interacts with the RanGTPase cycle in Saccharomyces cerevisiae. J Cell Sci 109 ( Pt 9):2311-8
3) Nakashima N, et al.  (1999) Saccharomyces cerevisiae putative G protein, Gtr1p, which forms complexes with itself and a novel protein designated as Gtr2p, negatively regulates the Ran/Gsp1p G protein cycle through Gtr2p. Genetics 152(3):853-67
4) Hirose E, et al.  (1998) RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway. J Cell Sci 111 ( Pt 1):11-21
5) Palecek SP, et al.  (2000) Genetic analysis reveals that FLO11 upregulation and cell polarization independently regulate invasive growth in Saccharomyces cerevisiae. Genetics 156(3):1005-23
6) Gao M and Kaiser CA  (2006) A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast. Nat Cell Biol 8(7):657-67
7) Sekiguchi T, et al.  (2008) Genetic evidence that Ras-like GTPases, Gtr1p, and Gtr2p, are involved in epigenetic control of gene expression in Saccharomyces cerevisiae. Biochem Biophys Res Commun 368(3):748-54
8) Panchaud N, et al.  (2013) Amino Acid Deprivation Inhibits TORC1 Through a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr1. Sci Signal 6(277):ra42