Standard Name	NDI1 1
Systematic Name	YML120C
Feature Type	ORF, Verified
Description	NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; involved in Mn and H2O2 induced apoptosis; upon apoptotic stress, Ndip is activated in the mitochondria by N-terminal cleavage, and the truncated protein translocates to the cytoplasm to induce apoptosis; homolog of human AMID (1, 2, 3, 4, 5)
Name Description	NADH Dehydrogenase Internal 1

Chromosomal Location	ChrXIII:29807 to 28266 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for NDI1
Molecular Function
Manually curated	NADH dehydrogenase (ubiquinone) activity (IDA)
Biological Process
Manually curated	chronological cell aging (IMP) mitochondrial electron transport, NADH to ubiquinone (IDA) NADH oxidation (IDA) positive regulation of apoptotic process (IMP)
Cellular Component
Manually curated	mitochondrial matrix (IDA, IMP) mitochondrion (IDA)
High-throughput	mitochondrion (IDA)

Pathways	aerobic respiration, electron transport chain

Classical genetics
null	apoptosis: decreased lifespan: increased resistance to artemisinin: increased toxin resistance: increased utilization of carbon source: absent utilization of carbon source: decreased
overexpression	apoptosis: increased reactive oxygen species accumulation: increased vegetative growth: decreased rate
Large-scale survey
null	competitive fitness: decreased resistance to oleate: decreased resistance to trichothecene: increased resistance to neomycin: decreased resistance to cycloheximide: decreased respiratory growth: decreased rate respiratory growth: absent respiratory growth: decreased sporulation efficiency: decreased utilization of carbon source: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	42 total interaction(s) for 33 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-Western: 1 Co-crystal Structure: 2 Co-purification: 1 PCA: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 1 Negative Genetic: 16 Phenotypic Enhancement: 3 Phenotypic Suppression: 1 Positive Genetic: 5 Synthetic Lethality: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:29807 to 28266 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1542 29807..28266 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004589