Standard Name	COQ5
Systematic Name	YML110C
Alias	DBI56
Feature Type	ORF, Verified
Description	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes (1, 2, 3)
Name Description	COenzyme Q
Gene Product Alias	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase 1

Chromosomal Location	ChrXIII:50954 to 50031 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for COQ5
Molecular Function
Manually curated	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity (IMP, ISS)
Biological Process
Manually curated	aerobic respiration (IMP) ubiquinone biosynthetic process (IMP)
Cellular Component
Manually curated	mitochondrial matrix (IDA)
High-throughput	mitochondrion (IDA)

Pathways	superpathway of ubiquinone biosynthesis ubiquinone biosynthesis

Classical genetics
null	3-hexaprenyl-4-hydroxybenzoic acid accumulation: increased chronological lifespan: decreased Coq3p accumulation: decreased resistance to linoleic acid: decreased respiratory growth: absent
Large-scale survey
null	cell cycle progression in G1 phase: increased duration glycogen accumulation: decreased competitive fitness: decreased dessication resistance: decreased heat sensitivity: increased resistance to ethanol: decreased resistance to trichothecene: increased respiratory growth: absent respiratory growth: decreased rate utilization of carbon source: decreased vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	13 total interaction(s) for 12 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 2 Affinity Capture-Western: 1 Biochemical Activity: 1 Reconstituted Complex: 1 Two-hybrid: 6
Genetic Interactions	Phenotypic Enhancement: 1 Synthetic Growth Defect: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:50954 to 50031 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..924 50954..50031 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004578