ZDS2/YML109W Summary Help

Standard Name ZDS2 1, 2, 3, 4
Systematic Name YML109W
Alias CES4 5
Feature Type ORF, Verified
Description Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication (2, 6, 7, 8, 9, 10)
Name Description Zillion Different Screens 1, 2
Chromosomal Location
ChrXIII:51640 to 54468 | ORF Map | GBrowse
Gene Ontology Annotations All ZDS2 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Classical genetics
Large-scale survey
128 total interaction(s) for 76 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 24
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 4
  • Co-purification: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 40

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 11
  • Negative Genetic: 14
  • Phenotypic Enhancement: 6
  • Phenotypic Suppression: 8
  • Positive Genetic: 5
  • Synthetic Growth Defect: 9
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 942
Molecular Weight (Da) 105,495
Isoelectric Point (pI) 5.14
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXIII:51640 to 54468 | ORF Map | GBrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..2829 51640..54468 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004577
References cited on this page View Complete Literature Guide for ZDS2
1) Yu Y, et al.  (1996) Mutations in the homologous ZDS1 and ZDS2 genes affect cell cycle progression. Mol Cell Biol 16(10):5254-63
2) Bi E and Pringle JR  (1996) ZDS1 and ZDS2, genes whose products may regulate Cdc42p in Saccharomyces cerevisiae. Mol Cell Biol 16(10):5264-75
3) Stillman, D.  (1993) Personal Communication, Mortimer Map Edition 12
4) Jiang, Y.W. and Stillman, D.J.  (1994) Personal Communication, Mortimer Map Edition 12
5) Schwer B and Shuman S  (1996) Multicopy suppressors of temperature-sensitive mutations of yeast mRNA capping enzyme. Gene Expr 5(6):331-44
6) Roy N and Runge KW  (1999) The ZDS1 and ZDS2 proteins require the Sir3p component of yeast silent chromatin to enhance the stability of short linear centromeric plasmids. Chromosoma 108(3):146-61
7) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
8) Queralt E and Uhlmann F  (2008) Separase cooperates with Zds1 and Zds2 to activate Cdc14 phosphatase in early anaphase. J Cell Biol 182(5):873-83
9) Yasutis K, et al.  (2010) Zds2p Regulates Swe1p-dependent Polarized Cell Growth in Saccharomyces cerevisiae via a Novel Cdc55p Interaction Domain. Mol Biol Cell 21(24):4373-86
10) Rossio V and Yoshida S  (2011) Spatial regulation of Cdc55-PP2A by Zds1/Zds2 controls mitotic entry and mitotic exit in budding yeast. J Cell Biol 193(3):445-54