GIM5/YML094W Summary Help

Standard Name GIM5 1
Systematic Name YML094W
Alias PFD5
Feature Type ORF, Verified
Description Subunit of the heterohexameric cochaperone prefoldin complex; prefoldin binds specifically to cytosolic chaperonin and transfers target proteins to it; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation (1, 2, 3, 4)
Name Description Gene Involved in Microtubule biogenesis 1
Chromosomal Location
ChrXIII:82275 to 82849 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All GIM5 GO evidence and references
  View Computational GO annotations for GIM5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 153 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
997 total interaction(s) for 530 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 20
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 5
  • PCA: 2
  • Two-hybrid: 5

Genetic Interactions
  • Negative Genetic: 451
  • Phenotypic Enhancement: 10
  • Phenotypic Suppression: 4
  • Positive Genetic: 254
  • Synthetic Growth Defect: 166
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 77

Resources
Expression Summary
histogram
Resources
Length (a.a.) 163
Molecular Weight (Da) 18,356
Isoelectric Point (pI) 9.51
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:82275 to 82849 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..16 82275..82290 1996-07-31 1996-07-31
Intron 17..99 82291..82373 1996-07-31 1996-07-31
CDS 100..575 82374..82849 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004559
References cited on this page View Complete Literature Guide for GIM5
1) Geissler S, et al.  (1998) A novel protein complex promoting formation of functional alpha- and gamma-tubulin. EMBO J 17(4):952-66
2) Vainberg IE, et al.  (1998) Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. Cell 93(5):863-73
3) Brew CT and Huffaker TC  (2002) The yeast ubiquitin protease, Ubp3p, promotes protein stability. Genetics 162(3):1079-89
4) Millan-Zambrano G, et al.  (2013) The Prefoldin Complex Regulates Chromatin Dynamics during Transcription Elongation. PLoS Genet 9(9):e1003776