Standard Name	UFO1 1
Systematic Name	YML088W
Feature Type	ORF, Verified
Description	F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation (1)
Name Description	UV-F-box-HO 1

Chromosomal Location	ChrXIII:92235 to 94241 | ORF Map | GBrowse

	View Computational GO annotations for UFO1
Molecular Function
Manually curated	protein binding, bridging (ISA) contributes_to ubiquitin-protein ligase activity (IC, ISA)
Biological Process
Manually curated	cellular response to methylmercury (IMP) response to DNA damage stimulus (IMP) SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (IMP, IPI)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA) SCF ubiquitin ligase complex (IDA, IPI)
High-throughput	cytoplasm (IDA)

Classical genetics
null	chromosome/plasmid maintenance: abnormal
overexpression	resistance to methylmercury chloride: increased
Large-scale survey
null	cell size: decreased resistance to 2,4-dichlorophenol: decreased resistance to tunicamycin: decreased viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	68 total interaction(s) for 35 unique genes/features.
Physical Interactions	Affinity Capture-MS: 15 Affinity Capture-RNA: 2 Affinity Capture-Western: 22 Biochemical Activity: 1 Reconstituted Complex: 9 Two-hybrid: 6
Genetic Interactions	Dosage Growth Defect: 5 Dosage Lethality: 1 Dosage Rescue: 1 Positive Genetic: 4 Synthetic Growth Defect: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:92235 to 94241 | ORF Map | GBrowse
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2007 92235..94241 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004553