UFO1/YML088W Summary

UFO1 BASIC INFORMATION

Standard Name	UFO1 1
Systematic Name	YML088W
Feature Type	ORF, Verified
Description	F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation (1)
Name Description	UV-F-box-HO 1

GO Annotations	All UFO1 GO evidence and references
	View Computational GO annotations for UFO1
Molecular Function
Manually curated	protein binding (IDA) ubiquitin-protein ligase activity (IMP)
Biological Process
Manually curated	response to DNA damage stimulus (IMP, IPI) ubiquitin-dependent protein catabolic process (IMP, IPI)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA) SCF ubiquitin ligase complex (IPI)
High-throughput	cytoplasm (IDA)

Mutant Phenotype	All UFO1 Phenotype details and references
Classical genetics
overexpression	resistance to methylmercury chloride: increased
Large-scale survey
null	viable

Interactions	UFO1 All interactions details and references
	38 total interaction(s) for 19 unique genes/features.
Physical Interactions	Affinity Capture-MS: 14 Affinity Capture-RNA: 1 Affinity Capture-Western: 8 Reconstituted Complex: 8 Two-hybrid: 6
Genetic Interactions	Synthetic Growth Defect: 1

Sequence Information

ChrXIII:92235 to 94241 | |

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2007	92235..94241	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004553

UFO1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for UFO1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for UFO1]

1)	Kaplun L, et al. (2003) DNA damage response-mediated degradation of Ho endonuclease via the ubiquitin system involves its nuclear export. J Biol Chem 278(49):48727-34

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