Standard Name	TEM1 (see Nomenclature conflict Note)
Systematic Name	YML064C
Feature Type	ORF, Verified
Description	GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis (1, 2, 3)
Name Description	TErmination of M phase 1

Chromosomal Location	ChrXIII:145876 to 145139 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for TEM1
Molecular Function
Manually curated	GTPase activity (IDA) protein binding (IPI)
Biological Process
Manually curated	regulation of exit from mitosis (TAS)
Cellular Component
Manually curated	spindle pole body (IDA)

Regulatory modules	predicted: cellcycle (221)

Classical genetics
conditional	cell cycle progression in telophase: arrested heat sensitivity: increased nuclear position: abnormal Spc42p distribution: abnormal Kar9p distribution: abnormal spindle morphology: abnormal
null	inviable
Large-scale survey
conditional	chromosome/plasmid maintenance: abnormal
null	inviable lifespan: increased
reduction of function	competitive fitness: decreased resistance to hydroxyurea: decreased resistance to sirolimus: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	205 total interaction(s) for 122 unique genes/features.
Physical Interactions	Affinity Capture-MS: 43 Affinity Capture-RNA: 2 Affinity Capture-Western: 27 Biochemical Activity: 5 Co-localization: 3 PCA: 1 Protein-RNA: 1 Reconstituted Complex: 5 Two-hybrid: 49
Genetic Interactions	Dosage Lethality: 6 Dosage Rescue: 26 Phenotypic Enhancement: 4 Phenotypic Suppression: 4 Synthetic Growth Defect: 8 Synthetic Lethality: 9 Synthetic Rescue: 12
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:145876 to 145139 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..738 145876..145139 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004529