Standard Name	SML1 1
Systematic Name	YML058W
Feature Type	ORF, Verified
Description	Ribonucleotide reductase inhibitor; involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase; SML1 has a paralog, DIF1, that arose from the whole genome duplication (2, 3, 4)
Name Description	Suppressor of Mec1 Lethality 1

Chromosomal Location	ChrXIII:159383 to 159697 | ORF Map | GBrowse

	View Computational GO annotations for SML1
Molecular Function
Manually curated	enzyme inhibitor activity (IDA)
Biological Process
Manually curated	mitochondrion organization (IMP) response to DNA damage stimulus (IMP)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA)

Classical genetics
null	2'-deoxyribonucleoside 5'-triphosphate accumulation: increased heat sensitivity: decreased mitochondrial genome maintenance: abnormal pseudohyphal growth: decreased resistance to hydroxyurea: decreased resistance to hydroxyurea: normal viable
Large-scale survey
null	competitive fitness: increased resistance to fluconazole: increased resistance to hydroxyurea: decreased resistance to cadmium sulfate: decreased starvation resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	239 total interaction(s) for 124 unique genes/features.
Physical Interactions	Affinity Capture-MS: 30 Affinity Capture-RNA: 3 Affinity Capture-Western: 2 Biochemical Activity: 7 Co-crystal Structure: 1 Protein-RNA: 1 Reconstituted Complex: 3 Two-hybrid: 7
Genetic Interactions	Dosage Growth Defect: 4 Dosage Lethality: 1 Dosage Rescue: 3 Negative Genetic: 2 Phenotypic Enhancement: 42 Phenotypic Suppression: 18 Synthetic Growth Defect: 41 Synthetic Lethality: 21 Synthetic Rescue: 53
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:159383 to 159697 | ORF Map | GBrowse
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..315 159383..159697 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004523