Standard Name	CMP2 1
Systematic Name	YML057W
Alias	CNA2 2
Feature Type	ORF, Verified
Description	Calcineurin A; one isoform (the other is Cna1p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1; CMP2 has a paralog, CNA1, that arose from the whole genome duplication (3, 4, 5, 6)
Name Description	CalModulin binding Protein 1

Chromosomal Location	ChrXIII:160180 to 161994 | ORF Map | GBrowse

	View Computational GO annotations for CMP2
Molecular Function
Manually curated	contributes_to calcium-dependent protein serine/threonine phosphatase activity (IDA)
Biological Process
Manually curated	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion (IMP) cellular ion homeostasis (IMP)
Cellular Component
Manually curated	calcineurin complex (IDA, IPI)
High-throughput	cytoplasm (IDA)

Regulatory modules	predicted: cellcycle (371, 287)

Classical genetics
null	recovery from pheromone-induced cell cycle arrest: decreased resistance to Plakortide F Acid: decreased
overexpression	replicative lifespan: decreased viability: decreased
Large-scale survey
null	UV resistance: decreased competitive fitness: decreased haploinsufficient resistance to arsenite(3-): decreased resistance to sirolimus: increased resistance to mycophenolic acid: increased resistance to hydroxyurea: increased resistance to cycloheximide: increased resistance to camptothecin: increased resistance to caffeine: decreased resistance to bleomycin: increased resistance to tunicamycin: decreased resistance to fluconazole: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	72 total interaction(s) for 48 unique genes/features.
Physical Interactions	Affinity Capture-MS: 23 Affinity Capture-Western: 3 Biochemical Activity: 1 Co-purification: 1 Reconstituted Complex: 3 Two-hybrid: 4
Genetic Interactions	Dosage Lethality: 2 Dosage Rescue: 3 Negative Genetic: 7 Positive Genetic: 14 Synthetic Growth Defect: 5 Synthetic Lethality: 4 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:160180 to 161994 | ORF Map | GBrowse
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1815 160180..161994 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004521