PRM6/YML047C Summary Help

Standard Name PRM6 1
Systematic Name YML047C
Alias KCH2 2
Feature Type ORF, Verified
Description Potassium transporter that mediates K+ influx; activates high-affinity Ca2+ influx system (HACS) during mating pheromone response; expression up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; member of a fungal-specific gene family; PRM6 has a paralog, KCH1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Pheromone-Regulated Membrane protein 1
Chromosomal Location
ChrXIII:181075 to 180017 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PRM6 GO evidence and references
  View Computational GO annotations for PRM6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Large-scale survey
null
overexpression
Resources
38 total interaction(s) for 33 unique genes/features.
Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Rescue: 2
  • Negative Genetic: 22
  • Phenotypic Enhancement: 3
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 352
Molecular Weight (Da) 41,372
Isoelectric Point (pI) 8.77
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:181075 to 180017 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1059 181075..180017 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004510
References cited on this page View Complete Literature Guide for PRM6
1) Heiman MG and Walter P  (2000) Prm1p, a pheromone-regulated multispanning membrane protein, facilitates plasma membrane fusion during yeast mating. J Cell Biol 151(3):719-30
2) Stefan CP, et al.  (2013) Activation of an Essential Calcium Signaling Pathway in Saccharomyces cerevisiae by Kch1 and Kch2, Putative Low-Affinity Potassium Transporters. Eukaryot Cell 12(2):204-14
3) White JM and Rose MD  (2001) Yeast mating: getting close to membrane merger. Curr Biol 11(1):R16-20
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61