PRP39/YML046W Summary Help

Standard Name PRP39
Systematic Name YML046W
Feature Type ORF, Verified
Description U1 snRNP protein involved in splicing; contains multiple tetriatricopeptide repeats (1, 2, 3)
Name Description Pre-mRNA Processing
Chromosomal Location
ChrXIII:181474 to 183363 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PRP39 GO evidence and references
  View Computational GO annotations for PRP39
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Large-scale survey
null
reduction of function
Resources
90 total interaction(s) for 45 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 77
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Co-purification: 1
  • Two-hybrid: 4

Genetic Interactions
  • Dosage Lethality: 2
  • Negative Genetic: 1
  • Synthetic Lethality: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 629
Molecular Weight (Da) 74,747
Isoelectric Point (pI) 8.61
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:181474 to 183363 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1890 181474..183363 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004509
References cited on this page View Complete Literature Guide for PRP39
1) Lockhart SR and Rymond BC  (1994) Commitment of yeast pre-mRNA to the splicing pathway requires a novel U1 small nuclear ribonucleoprotein polypeptide, Prp39p. Mol Cell Biol 14(6):3623-33
2) Gottschalk A, et al.  (1998) A comprehensive biochemical and genetic analysis of the yeast U1 snRNP reveals five novel proteins. RNA 4(4):374-93
3) Zhang D and Rosbash M  (1999) Identification of eight proteins that cross-link to pre-mRNA in the yeast commitment complex. Genes Dev 13(5):581-92