CGI121/YML036W Summary Help

Standard Name CGI121 1
Systematic Name YML036W
Feature Type ORF, Verified
Description Component of the EKC/KEOPS complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; Cgi121p is dispensable for tRNA modification; other complex members are Bud32p, Kae1p, Pcc1p, and Gon7p (1, 2, 3, 4)
Chromosomal Location
ChrXIII:205642 to 206293 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CGI121 GO evidence and references
  View Computational GO annotations for CGI121
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Large-scale survey
null
Resources
34 total interaction(s) for 16 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 20
  • Affinity Capture-Western: 1
  • Far Western: 2
  • Reconstituted Complex: 1

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 1
  • Synthetic Lethality: 2
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 181
Molecular Weight (Da) 20,662
Isoelectric Point (pI) 6.03
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:205642 to 206293 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2007-07-10 | Sequence: 2007-07-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..456 205642..206097 2007-07-10 2007-07-10
Intron 457..562 206098..206203 2007-07-10 2007-07-10
CDS 563..652 206204..206293 2007-07-10 2007-07-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004500
References cited on this page View Complete Literature Guide for CGI121
1) Downey M, et al.  (2006) A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator. Cell 124(6):1155-68
2) Kisseleva-Romanova E, et al.  (2006) Yeast homolog of a cancer-testis antigen defines a new transcription complex. EMBO J 25(15):3576-85
3) Srinivasan M, et al.  (2011) The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A. EMBO J 30(5):873-81
4) Hu Y, et al.  (2013) Telomerase-null survivor screening identifies novel telomere recombination regulators. PLoS Genet 9(1):e1003208