AMD1/YML035C Summary Help

Standard Name AMD1
Systematic Name YML035C
Alias AMD3
Feature Type ORF, Verified
Description AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools (1, 2, 3, 4, 5, 6)
Name Description AMP Deaminase
Chromosomal Location
ChrXIII:208860 to 206428 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All AMD1 GO evidence and references
  View Computational GO annotations for AMD1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 1 genes
Resources
Pathways
Classical genetics
null
reduction of function
Large-scale survey
null
Resources
93 total interaction(s) for 83 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Biochemical Activity: 11
  • PCA: 2
  • Protein-peptide: 5
  • Protein-RNA: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 6

Genetic Interactions
  • Negative Genetic: 43
  • Phenotypic Enhancement: 2
  • Positive Genetic: 14
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 810
Molecular Weight (Da) 93,301
Isoelectric Point (pI) 6.59
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:208860 to 206428 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2433 208860..206428 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004498
References cited on this page View Complete Literature Guide for AMD1
1) Merkler DJ and Schramm VL  (1990) Catalytic and regulatory site composition of yeast AMP deaminase by comparative binding and rate studies. Resolution of the cooperative mechanism. J Biol Chem 265(8):4420-6
2) Merkler DJ, et al.  (1989) AMP deaminase from yeast. Role in AMP degradation, large scale purification, and properties of the native and proteolyzed enzyme. J Biol Chem 264(35):21422-30
3) Sagot I, et al.  (2005) Guanylic nucleotide starvation affects Saccharomyces cerevisiae mother-daughter separation and may be a signal for entry into quiescence. BMC Cell Biol 6(1):24
4) Gauthier S, et al.  (2008) Co-regulation of yeast purine and phosphate pathways in response to adenylic nucleotide variations. Mol Microbiol 68(6):1583-94
5) Saint-Marc C, et al.  (2009) Phenotypic consequences of purine nucleotide imbalance in Saccharomyces cerevisiae. Genetics 183(2):529-38, 1SI-7SI
6) Walther T, et al.  (2010) Control of ATP homeostasis during the respiro-fermentative transition in yeast. Mol Syst Biol 6():344