SRC1/YML034W Summary Help

Standard Name SRC1 1
Systematic Name YML034W
Alias YML033W , HEH1 2
Feature Type ORF, Verified
Description Inner nuclear membrane protein; highly enriched at telomeres and subtelomeric regions; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance; SEC1 has a paralog, HEH2, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6, 7, 8)
Name Description Spliced mRNA and Cell cycle regulated gene 1
Chromosomal Location
ChrXIII:209525 to 212155 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SRC1 GO evidence and references
  View Computational GO annotations for SRC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
285 total interaction(s) for 163 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 14
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 3
  • Biochemical Activity: 1
  • Co-localization: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 210
  • Phenotypic Enhancement: 4
  • Positive Genetic: 10
  • Synthetic Growth Defect: 30
  • Synthetic Lethality: 6

Resources
Expression Summary
histogram
Resources
Length (a.a.) 834
Molecular Weight (Da) 95,497
Isoelectric Point (pI) 5.35
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:209525 to 212155 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1998-11-10 | Sequence: 1998-11-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1920 209525..211444 1998-11-10 1998-11-10
Intron 1921..2046 211445..211570 1998-11-10 1998-11-10
CDS 2047..2631 211571..212155 1998-11-10 1998-11-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004497
References cited on this page View Complete Literature Guide for SRC1
1) Rodriguez-Navarro S, et al.  (2002) SRC1: an intron-containing yeast gene involved in sister chromatid segregation. Yeast 19(1):43-54
2) King MC, et al.  (2006) Karyopherin-mediated import of integral inner nuclear membrane proteins. Nature 442(7106):1003-7
3) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6) Grund SE, et al.  (2008) The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression. J Cell Biol 182(5):897-910
7) Torres EM, et al.  (2010) Identification of aneuploidy-tolerating mutations. Cell 143(1):71-83
8) Mishra SK, et al.  (2011) Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing. Nature ()