Standard Name	NDC1 1, 2
Systematic Name	YML031W
Feature Type	ORF, Verified
Description	Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1 (1, 3, 4, 5, 6, 7)
Name Description	Nuclear Division Cycle 1

Chromosomal Location	ChrXIII:214189 to 216156 | ORF Map | GBrowse
	Genetic position: -18 cM

	View Computational GO annotations for NDC1
Molecular Function
Manually curated	structural constituent of nuclear pore (IC)
Biological Process
Manually curated	nuclear pore organization (IGI, IMP) nucleocytoplasmic transport (IC) spindle pole body duplication associated with nuclear envelope (IMP)
Cellular Component
Manually curated	nuclear pore (IDA) nuclear pore transmembrane ring (IDA, IPI) spindle pole body (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
conditional	chromosome segregation: abnormal
Large-scale survey
null	competitive fitness: decreased haploinsufficient heat sensitivity: increased inviable
overexpression	vegetative growth: decreased
reduction of function	competitive fitness: increased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	77 total interaction(s) for 51 unique genes/features.
Physical Interactions	Affinity Capture-MS: 29 Affinity Capture-Western: 3 Biochemical Activity: 1 Co-fractionation: 1 Co-purification: 1 PCA: 8 Reconstituted Complex: 3 Two-hybrid: 4
Genetic Interactions	Dosage Growth Defect: 4 Dosage Rescue: 6 Phenotypic Enhancement: 1 Phenotypic Suppression: 3 Synthetic Growth Defect: 6 Synthetic Lethality: 1 Synthetic Rescue: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:214189 to 216156 | ORF Map | GBrowse
	Genetic position: -18 cM
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1968 214189..216156 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004493