NDC1/YML031W Summary Help

Standard Name NDC1 1, 2
Systematic Name YML031W
Feature Type ORF, Verified
Description Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1 (1, 3, 4, 5, 6, 7)
Name Description Nuclear Division Cycle 1
Chromosomal Location
ChrXIII:214189 to 216156 | ORF Map | GBrowse
Gbrowse
Genetic position: -18 cM
Gene Ontology Annotations All NDC1 GO evidence and references
  View Computational GO annotations for NDC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 107 genes
Resources
Classical genetics
conditional
Large-scale survey
null
overexpression
reduction of function
Resources
86 total interaction(s) for 52 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 30
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 3
  • Biochemical Activity: 1
  • Co-fractionation: 1
  • Co-purification: 1
  • PCA: 8
  • Reconstituted Complex: 3
  • Two-hybrid: 8

Genetic Interactions
  • Dosage Growth Defect: 4
  • Dosage Rescue: 7
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 3
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 1
  • Synthetic Rescue: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 655
Molecular Weight (Da) 74,133
Isoelectric Point (pI) 8.41
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:214189 to 216156 | ORF Map | GBrowse
SGD ORF map
Genetic position: -18 cM
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1968 214189..216156 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004493
References cited on this page View Complete Literature Guide for NDC1
1) Thomas JH and Botstein D  (1986) A gene required for the separation of chromosomes on the spindle apparatus in yeast. Cell 44(1):65-76
2) Hoyt, A.  (1989) Personal Communication, Mortimer Map Edition 10
3) Chial HJ, et al.  (1999) Altered dosage of the Saccharomyces cerevisiae spindle pole body duplication gene, NDC1, leads to aneuploidy and polyploidy. Proc Natl Acad Sci U S A 96(18):10200-5
4) Rout MP, et al.  (2000) The yeast nuclear pore complex: composition, architecture, and transport mechanism. J Cell Biol 148(4):635-51
5) Lau CK, et al.  (2004) A novel allele of Saccharomyces cerevisiae NDC1 reveals a potential role for the spindle pole body component Ndc1p in nuclear pore assembly. Eukaryot Cell 3(2):447-58
6) Onischenko E, et al.  (2009) Role of the Ndc1 interaction network in yeast nuclear pore complex assembly and maintenance. J Cell Biol 185(3):475-91
7) Fernandez-Martinez J and Rout MP  (2009) Nuclear pore complex biogenesis. Curr Opin Cell Biol 21(4):603-12